Sphingomyelin Metabolism Is a Regulator of K-Ras Function
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چکیده
منابع مشابه
Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras.
K-Ras mutations are frequent in colorectal cancer (CRC), albeit K-Ras is the only Ras isoform that can elicit apoptosis. Here, we show that mutant K-Ras directly binds to the tumor suppressor RASSF1A to activate the apoptotic MST2-LATS1 pathway. In this pathway LATS1 binds to and sequesters the ubiquitin ligase Mdm2 causing stabilization of the tumor suppressor p53 and apoptosis. However, mutan...
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In mammals, the three classical ras genes encode four highly homologous proteins, N-Ras, H-Ras, and the isoforms K-Ras 4A and 4B. Previous studies have shown that K-ras is essential for mouse development and that while K-ras 4A and 4B are expressed during development, K-ras 4A expression is regulated temporally and spatially and occurs in adult kidney, intestine, stomach, and liver. In the pres...
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WNK kinases [with no lysine (K) kinase] are emerging as regulators of several membrane transport proteins in which WNKs act as molecular switches that coordinate the activity of several players. Members of the cation-coupled chloride cotransporters family (solute carrier family number 12) are one of the main targets. WNK3 activates the Na(+)-driven cotransporters NCC, NKCC1, and NKCC2 and inhib...
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A large haplotype on chromosome 19p13.11 tagged by rs10401969 in intron 8 of SURP and G patch domain containing 1 (SUGP1) is associated with coronary artery disease (CAD), plasma LDL cholesterol levels, and other energy metabolism phenotypes. Recent studies have suggested that TM6SF2 is the causal gene within the locus, but we postulated that this locus could harbor additional CAD risk genes, i...
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Expression Array Analyses Genome-wide gene expression of 480 LCLs established from participants of the Cholesterol and Pharmacogenetics (CAP) clinical trial were incubated with either 2μM activated simvastatin or sham buffer for 24 hours. Simvastatin was obtained as a gift from Merck and activated as previously described. RNA was extracted, converted into the cRNA and quantified using the Illum...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2018
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.00373-17